4D biofabrication of skeletal muscle microtissues

Contractile Skeletal Muscle Microtissues in Microchannel

This paper reports a development of the microfluidic device for fabrication and cultivation of contractile skeletal muscle tissue in microchannels. Microfluidic processes were only used to develop contractile skeletal muscle microtissues in microchannels. Thus, the volume of the collagen gel used to fabricate the microtissues can be defined precisely. The fabricated microtissues can be cultured...

Biofabrication of Tissue Scaffolds

Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.

Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main prope...

Skeletal Muscle

The modulation by internal free [Mg 2 1 ] of spontaneous calcium release events (Ca 2 1 “sparks”) from the sarcoplasmic reticulum (SR) was studied in depolarized notched frog skeletal muscle fibers using a laser scanning confocal microscope in line-scan mode ( x vs. t ). Over the range of [Mg 2 1 ] from 0.13 to 1.86 mM, decreasing the [Mg 2 1 ] induced an increase in the frequency of calcium re...

Role of resistance training with the approach of blood flow restriction in skeletal muscle cell growth

Background: The aim of this study was to investigate the response of ERK1/2 protein and muscular morphological adaptations to a period of resistance training with local blood flow restriction. Materials and methods: Twenty healthy male Wistar rats without clinically evident disease (5 weeks old, 120±7 g weight) were divided into four equal groups: control, control with limited blood flow...